| Title | Are one or two dangerous? Diphenoxylate-atropine exposure in toddlers. | | Author(s) | Thomas TJ, Pauze D, Love JN | | Institution | Department of Emergency Medicine, George Washington University, Washington, DC. | | Source | J Emerg Med 2007 Aug 29. | | Abstract | Lomotil(R) (Pfizer Inc., New York, NY) (diphenoxylate-atropine) is said to be potentially toxic to toddlers with exposure to as little as one to two tablets. A review of the data on diphenoxylate-atropine poisonings from the American Association of Poison Control Centers annual reports, review articles, and case series disputes this view. Fatalities associated with diphenoxylate-atropine have been reported in toddlers after repetitive or incorrect dosages. Fortunately, trends in pediatric diphenoxylate-atropine ingestions are decreasing. We review the management, trends, and current concepts regarding pediatric diphenoxylate-atropine ingestions. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17976801 |
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