Stayoussef M, Al-Jenaidi FA, Al-Abbasi A, Al-Ola K, Khayyat H, Mahjoub T, Almawi WY
Modulation of Type 1 Diabetes Susceptibility by TNF{alpha} -308G/A and Lymphotoxin-{alpha} +249A/G Haplotypes in Bahraini Patients: Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes. [JOURNAL ARTICLE]
Clin Vaccine Immunol 2007 Nov 7.
TNFalpha -308G/A and LTalpha +249A/G were investigated in 228 type-1 diabetes (T1DM) patients and 240 controls. Only LTalpha +249G allele and +249G/+249G genotype frequencies were higher among patients, and no LD was found between TNFalpha/LTalpha alleles and susceptible/protective DRB1-DQB1 haplotypes TNFalpha/LTalpha T1DM susceptible (-308G/+249G) and protective (-308G/+249A) haplotypes were identified.
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