| Title | Low-dose haloperidol prevents post-operative nausea and vomiting after ambulatory laparoscopic surgery. | | Author(s) | Wang TF, Liu YH, Chu CC, Shieh JP, Tzeng JI, Wang JJ | | Institution | Department of Anaesthesiology, Chi-Mei Medical Centre, Tainan, Taiwan. | | Source | Acta Anaesthesiol Scand 2007 Nov 12. | | Abstract | Background: We evaluated the prophylactic effect of low-dose haloperidol (1 mg) on post-operative nausea and vomiting (PONV) in women undergoing ambulatory laparoscopic surgery. Droperidol (0.625 mg) and saline were controls.
Methods: One hundred and fifty women undergoing ambulatory laparoscopic surgery under general anaesthesia were enrolled in this randomized, double-blind, and placebo-controlled study. After tracheal intubation, the haloperidol group (n=50) received intravenous haloperidol (1 mg), the droperidol group (n=50) received intravenous droperidol (0.625 mg), and the saline group (n=50) received intravenous saline.
Results: Haloperidol- and droperidol-group patients reported a lower incidence of PONV [24% and 23% vs. 49% (saline group); P<0.05] and requested fewer doses of rescue antiemetics [13% and 16% vs. 38% (saline group); P<0.05] during the first four post-operative hours. During the 24-h post-operative period, haloperidol- and droperidol-group patients also reported a lower incidence of PONV [31% and 32% vs. 62% (saline group); P<0.01]. No differences were found between the haloperidol and droperidol groups.
Conclusion: Like droperidol (0.625 mg), prophylactic intravenous haloperidol (1 mg) significantly reduced the incidence of PONV in women undergoing ambulatory laparoscopic surgery. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 17999708 |
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