| Title | Prognostic Role of Left Atrial Volume in Elderly Patients with Symptomatic Stable Chronic Heart Failure: Comparison with Left Ventricular Diastolic Dysfunction and B-Type Natriuretic Peptide. | | Author(s) | Popescu BA, Popescu AC, Antonini-Canterin F, Rubin D, Cappelletti P, Piazza R, Ginghina C, Dimulescu D, Beladan CC, Nicolosi GL | | Institution | “Prof. Dr. C. C. Iliescu” Institute of Cardiovascular Diseases, Bucharest, Romania. | | Source | Echocardiography 2007 Nov; 24(10):1035-1043. | | Abstract | Background: Left atrial (LA) volume and B-type natriuretic peptide (BNP) represent powerful outcome predictors in patients with heart failure (HF).Aim: To assess the comparative prognostic role of LA volume (indexed to body surface area, LAVi), left ventricular diastolic dysfunction (LVDD) and BNP levels on long-term outcome in patients with symptomatic but stable chronic HF.
Methods: We studied consecutively 46 patients with symptomatic stable chronic HF (73 +/- 10 years, 30 men), in sinus rhythm, without significant valvular disease. Echocardiographic measurements included: LV mass, LV volumes and ejection fraction, and LAVi. LVDD was graded using a comprehensive Doppler algorithm. Blood taken before echocardiography was assayed for BNP levels. Primary end point was combined: all-cause mortality and hospitalization for worsening HF.
Results: During 20 +/- 14 months of follow-up 19 events occurred: 8 deaths, and 11 hospitalizations for HF. In univariate analyses LAVi, LVDD, BNP levels, LV ejection fraction, LV volumes, and LV mass were significant outcome predictors (P < 0.05). At multivariate regression LAVi was the only independent predictor of outcome (hazard ratio: 1.03 per 1 ml/m(2) increase, 95% CI: 1.01-1.06, P = 0.02).
Conclusion: Although directly related to LVDD and to BNP levels, only LAVi emerged as an independent outcome predictor in this cohort of elderly patients with symptomatic stable chronic HF. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18001356 |
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