| Title | Interleukin-2 inhalation Therapy Temporarily Induces Asthma-like Airway Inflammation. | | Author(s) | Loppow D, Huland E, Heinzer H, Grönke L, Magnussen H, Holz O, Jörres RA | | Institution | Institute and Outpatient Clinic for Occupational and Environmental Medicine, Ludwig-Maximilians-University Munich, Ziemssenstr. 1, 80336 Munich, Germany. rudolf.joerres@med.uni-muenchen.de. | | Source | Eur J Med Res 2007 Nov 5; 12(11):556-62. | | Abstract | Background: Inhaled interleukin-2 (IL-2) is an effective and safe treatment in metastasing renal cell carcinoma (mRCC) but known to potentially elicit respiratory symptoms. -
Objectives: The present study analyses the effects of IL-2 using a panel of measures including markers of airway inflammation. -
Methods: Ten patients with mRCC (7m/3f; mean age, 63 yrs) were measured at baseline, 6-10 days after start of therapy (n = 5, inhaled IL-2 only; n = 5, inhaled IL-2 plus 1/11 supersetth of daily dose subcutaneously), and 16-29 days later under continuous combined (inhaled plus subcutaneous) therapy, including additional subcutaneous IFN-alpha in 8 patients. -
Results: After start of therapy median FEV subset1 declined from 108 to 85 to 90 % predicted and the provocative concentration of methacholine elicting a 20 % fall in FEV subset1 (PC subset20 FEV subset1) from 16 to 8 to 3 mg/mL, while the level of exhaled nitric oxide (FENO) rose from 27 to 79 to 60 ppb and the percentage of sputum eosinophils from 2 to 18 to 37 % (p<0.01, each), accompanied by cough and dyspnoea (p<0.05). One patient who stopped therapy, was back to baseline values when measured 2 months later. Cytokine production by blood or sputum T lymphocytes was not markedly altered by IL-2 inhalation. -
Conclusions: IL-2 inhalation therapy in patients with metastasing renal cell carcinoma is capable of temporarily inducing symptomatic, functional and inflammatory alterations similar to those of bronchial asthma. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18024264 |
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