| Title | Synthesis and properties of umbelliferone-nitroxide radical hybrid compounds as fluorescence and spin-label probes. | | Author(s) | Sato S, Suzuki M, Soma T, Tsunoda M | | Institution | Department of Chemistry and Chemical Engineering, Faculty of Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa-shi, Yamagata 992-8510, Japan. | | Source | Spectrochim Acta A Mol Biomol Spectrosc 2007 Sep 25. | | Abstract | Two hybrid compounds 6 and 7, linked via an ester-bond between the 7-hydroxyl residue of an umbelliferone 1 and a carboxylic acid residue of two nitroxide radicals 3 and 4, and one hybrid compound 8, linked via an ester-bond between a 3-carboxylic acid residue of umbelliferone 2 and a hydroxyl residue of nitroxide radical 5, were synthesized in good yields, and their fluorescence and ESR spectra before and after the addition of l-ascorbic acid sodium salt in PBS (pH 7.0) were measured. The ESR intensities of 6 and 7 were proportionally reduced after the addition of ascorbic acid sodium salt, and their fluorescence intensities were increased maximally by eight- and nine-fold, respectively. However, the fluorescence intensity of 8 was essentially unchanged. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18029225 |
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