| Title | Clinical and Microbiological Outcomes of Serious Infections with Multidrug-Resistant Gram-Negative Organisms Treated with Tigecycline. | | Author(s) | Anthony KB, Fishman NO, Linkin DR, Gasink LB, Edelstein PH, Lautenbach E | | Institution | 1Division of Infectious Diseases, Department of Medicine, and Departments of 2Pathology and Laboratory Medicine and 3Biostatistics and Epidemiology, 4Center for Education and Research on Therapeutics, and 5Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia. | | Source | Clin Infect Dis 2008 Jan 16. | | Abstract | Eighteen patients received tigecycline as treatment for infection due to multidrug-resistant gram-negative bacilli, including Acinetobacter baumannii and Klebsiella pneumoniae carbapenemase- and extended-spectrum beta-lactamase-producing Enterobacteriaceae. Pretherapy minimum inhibitory concentration values for tigecycline predicted clinical success. Observed evolution of resistance during therapy raises concern about routine use of tigecycline in treatment of such infections when other therapies are available. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18199038 |
|
