Hoshi K, Fukuhara S
Effect of Lipo-PGE(1) on Health-related Quality of Life in Patients with Systemic Sclerosis and Systemic Lupus Erythematosus in Japan. [Journal Article]
J Int Med Res 2008 Jan-Feb; 36(1):187-97.
We investigated the effect of Lipo-PGE(1), a prostaglandin (PG) E(1) preparation used to treat cutaneous ulcers associated with systemic sclerosis (SS) and systemic lupus erythematosus (SLE), on health-related quality of life (HR-QOL) using the Medical Outcome Study 36-item Short-Form Health Survey (SF-36) questionnaire. A total of 192 SS and SLE patients were treated for 3 months. At baseline the scores for each of the five SF-36 subscales were significantly lower than the age- and sex-adjusted standard values for the Japanese general population. After treatment, mean (+/- SD) SF-36 scores for body pain and general health perception significantly increased from 48.6 +/- 24.1 to 55.3 +/- 26.1 and from 36.8 +/- 16.7 to 40.2 +/- 17, respectively. Emotional QOL parameters including vitality and mental health, however, showed no improvement. Physician-rated symptom scores significantly improved after administration of Lipo-PGE(1). In conclusion, Lipo-PGE(1) improved both cutaneous ulcers and HR-QOL, especially physical QOL.
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