The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. Journal of ethnopharmacology [J Ethnopharmacol] Journal article | | Title | The in vitro and ex vivo antioxidant properties, hypolipidaemic and antiatherosclerotic activities of water extract of Moringa oleifera Lam. leaves. | | Author(s) | Chumark P, Khunawat P, Sanvarinda Y, Phornchirasilp S, Morales NP, Phivthong-Ngam L, Ratanachamnong P, Srisawat S, Pongrapeeporn KU | | Institution | Department of Pharmacology, Siriraj Hospital, Mahidol University, Thailand. | | Source | J Ethnopharmacol 2008 Mar 28; 116(3):439-46. | | MeSH | Animals
Antioxidants
Atherosclerosis
Biphenyl Compounds
Body Weight
Cholesterol
Cholesterol, Dietary
Humans
Hypolipidemic Agents
Lipids
Lipoproteins, LDL
Male
Moringa oleifera
Picrates
Plant Extracts
Plant Leaves
Rabbits
Simvastatin
Thiobarbituric Acid Reactive Substances
Vitamin E
Water
| | Abstract | Moringa oleifera is used in Thai traditional medicine as cardiotonic. Recent studies demonstrated its hypocholesterolaemic effect. However, to be clinically useful, more scientific data are needed.We investigated the antioxidant, hypolipidaemic and antiatherosclerotic activities of Moringa oleifera leaf extract.Scavenging activity of the extract on 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), and the inhibitory effect on Cu(2+)-induced low-density lipoprotein (LDL) oxidation were determined in in vitro experiment. The effects of the extract on cholesterol levels, conjugated diene (CD) and thiobarbituric acid reactive substances (TBARS) and plaque formations in cholesterol-fed rabbits were investigated.We found that in scavenging DPPH radicals the extract and Trolox had IC(50) of 78.15+/-0.92 and 2.14+/-0.12microg/ml, respectively. The extract significantly (P<0.05) prolonged the lag-time of CD formation and inhibited TBARS formation in both in vitro and ex vivo experiments in a dose-dependent manner. In hypercholesterol-fed rabbits, at 12 weeks of treatment, it significantly (P<0.05) lowered the cholesterol levels and reduced the atherosclerotic plaque formation to about 50 and 86%, respectively. These effects were at degrees comparable to those of simvastatin.The results indicate that this plant possesses antioxidant, hypolipidaemic and antiatherosclerotic activities and has therapeutic potential for the prevention of cardiovascular diseases. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18249514 |
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