Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine. Archives of pharmacal research [Arch Pharm Res] Journal article

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Jung JW, Kim HD
Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine. [Journal Article, Research Support, Non-U.S. Gov't]
Arch Pharm Res 2007 Dec; 30(12):1521-5.

Hydroxyclemastine was targeted as a versatile analogue of clemastine with H1 receptor antagonist activity. Stereoselective synthesis of (-)-hydroxyclemastine was performed in which the key step was chelation-controlled diastereoselective 1,2-addition of Grignard reagent to alpha-alkoxyketone.

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Archives of pharmacal research

[Arch Pharm Res]

Related subjects (MeSH)

Clemastine

Histamine H1 Antagonists

Stereoisomerism

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