| Title | Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine. |
| Author(s) | Jung JW, Kim HD |
| Institution | College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea. |
| Source | Arch Pharm Res 2007 Dec; 30(12):1521-5. |
| MeSH | Clemastine
Histamine H1 Antagonists
Stereoisomerism
|
| Abstract | Hydroxyclemastine was targeted as a versatile analogue of clemastine with H1 receptor antagonist activity. Stereoselective synthesis of (-)-hydroxyclemastine was performed in which the key step was chelation-controlled diastereoselective 1,2-addition of Grignard reagent to alpha-alkoxyketone. |
| Language | eng |
| Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
|
| PubMed ID | 18254238 |
