Associations between tumor necrosis factor-{alpha} and lymphotoxin-{alpha} polymorphisms and idiopathic recurrent miscarriage. Reproduction (Cambridge, England) [Reproduction] Journal article | | Title | Associations between tumor necrosis factor-{alpha} and lymphotoxin-{alpha} polymorphisms and idiopathic recurrent miscarriage. | | Author(s) | Zammiti W, Mtiraoui N, Khairi H, Gris JC, Almawi WY, Mahjoub T | | Institution | Research Unit of Haematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia CHU Frahat Hached, Sousse, Tunisia Faculty of Biological and Pharmaceutical Sciences, Montpellier-1 University, Montpellier, F- 30029 France and Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, PO Box 22979, Manama, Bahrain. | | Source | Reproduction 2008 Mar; 135(3):397-403. | | Abstract | Heightened expression of tumor necrosis factor (TNF)-alpha and lymphotoxin-alpha (LT-alpha) was associated with pregnancy complications, including idiopathic recurrent miscarriage (RM). Whereas TNF-alpha and LT-alpha gene polymorphisms affect serum cytokine concentrations, their contribution to RM is controversial. The single nucleotide polymorphisms (SNPs) TNF-alpha (-238G/A, -308G/A) and LT-alpha (+252A/G) were investigated in 350 RM women and 200 control women. Higher frequency of the TNF-alpha -238A, but not the TNF-alpha -308A or the LT-alpha+252G, allele was seen in patients, with comparable frequencies of TNF-alpha -238G/A, TNF-alpha -308G/A, and LT-alpha+252A/G genotypes seen between both groups, except for TNF-alpha -238G/G, which was lower in patients. Regression analysis confirmed the association of the TNF-alpha -238G/A SNP with idiopathic RM, and both TNF-alpha -308A/TNF -238G/LT-alpha+252G and TNF-alpha -308G/TNF-alpha -238A/LT-alpha+252G haplotypes played a susceptible role in idiopathic RM. TNF-alpha -238G/A and -238A/A, and LT-alpha+252G/G genotypes were positively associated only with exclusively early RM. This supports the concept of the association of TNF-alpha (-238G/A) and LT-alpha (+252A/G) polymorphic variants in idiopathic RM. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18299433 |
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