Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study. AIDS (London, England) [AIDS] Journal article | | Title | Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study. | | Author(s) | Gupta SK, Johnson RM, Saha C, Mather KJ, Greenwald ML, Waltz JS, Rehman J, Dubé MP | | Institution | Indiana University School of Medicine, Indianapolis, Indiana, USA. | | Source | AIDS 2008 Mar 12; 22(5):653-5. | | Abstract | We hypothesized that heightened systemic inflammation contributes to the increased rate of cardiovascular events in HIV-infected patients not receiving combination antiretroviral therapy. We performed a pilot trial to assess the effects of the nuclear factor-kappaB inhibitor salsalate on flow-mediated dilation of the brachial artery, a measure of endothelial function. Flow-mediated dilation significantly improved after 8 weeks of salsalate. However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 18317009 |
|
|
| |
Advertise on this site.
| | |
|
