| Title | High Sensitivity C-Reactive Protein and Immunoglobulin G against Chlamydia Pneumoniae and Chlamydial Heat Shock Protein-60 in Ischemic Heart Disease. | | Author(s) | Jafarzadeh A, Esmaeeli-Nadimi A, Shariati M | | Institution | Department of Immunology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. | | Source | Iran J Immunol 2008 Mar; 5(1):51-6. | | Abstract | BACKGROUND: Inflammation and infectious agents such as Chlamydia pneumoniae have been associated with cardiovascular disease.
OBJECTIVE: To evaluate the serum high sensitivity C - reactive protein (hs-CRP) and antibodies against Chlamydia pneumoniae and Chlamydial heat shock protein-60 (Cp-HSP-60) in patients with ischemic heart disease (IHD).
METHODS: 62 patients with IHD having either acute myocardial infarction (AMI; n=31) or unstable angina (UA; n=31) and 31 sex- and age- matched healthy subjects as a control group were enrolled in this study. Serum samples of participants were tested for the presence of hs-CRP and antibodies against C. pneumoniae and Cp-HSP-60 using ELISA method.
RESULTS: The seroprevalence of anti-C. pneumoniae antibody in AMI group (93.5%) or UA group (90.3%) was significantly higher than the control group (61.3%; p<0.001). The seroprevalence of anti-Cp-HSP60 IgG was 22.6% in healthy subjects with mean end titer of 43.1 +/- 6.32. The seropositive rates of anti-Cp-HSP60 were 48.4%, 54.8% and 51.6% in AMI, UA and the overall IHD groups with mean end titers of 94 +/- 22.86, 113.8 +/- 24.25 and 103.9 +/- 16.57, respectively. Both the seroprevalence and the mean titer of anti-Cp-HSP60 in patients groups were significantly higher than those observed in the control group (p<0.04 and p<0.03, respectively). Moreover, the mean serum hs-CRP levels was significantly higher in the IHD group as compared to the control group (21.6 mug/ml +/- 3.73 vs 2.5 mug/ml +/- 0.52; p<0.00001). The mean serum hs-CRP levels of AMI (30.3 mug/ml +/- 6.07) or UA (12.9 mug/ml +/- 3.85) groups were also significantly higher than those observed in the control group (p<0.00001 and p<0.001, respectively). Furthermore, the difference of the mean serum hs-CRP levels between AMI and UA groups was also significant (p<0.02).
CONCLUSIONS: These results showed that the seroprevalence of antibodies against C. pneumoniae and Cp-HSP-60 and the serum levels of hs-CRP and anti-Cp-HSP60 IgG were higher in patients with IHD. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18319525 |
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