Efficacy of the combination of amlodipine and valsartan in patients with hypertension uncontrolled with previous monotherapy: the Exforge in Failure after Single Therapy (EX-FAST) study. Journal of clinical hypertension (Greenwich, Conn.) [J Clin Hypertens (Greenwich)] Journal article | | Title | Efficacy of the combination of amlodipine and valsartan in patients with hypertension uncontrolled with previous monotherapy: the Exforge in Failure after Single Therapy (EX-FAST) study. | | Author(s) | Allemann Y, Fraile B, Lambert M, Barbier M, Ferber P, Izzo JL | | Institution | Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Inselspital, Bern, Switzerland. | | Source | J Clin Hypertens (Greenwich) 2008 Mar; 10(3):185-94. | | MeSH | Amlodipine
Angiotensin II Type 1 Receptor Blockers
Antihypertensive Agents
Blood Pressure
Calcium Channel Blockers
Diabetes Mellitus, Type 2
Dose-Response Relationship, Drug
Double-Blind Method
Drug Therapy, Combination
Humans
Hydrochlorothiazide
Hypertension
Retreatment
Tetrazoles
Valine
| | Abstract | In this randomized, double-blind, multicenter study, patients whose blood pressure (BP) was uncontrolled by monotherapy were switched directly to amlodipine/valsartan 5/160 mg (n=443) or 10/160 mg (n=451). After 16 weeks, BP control (levels <140/90 mm Hg or <130/80 mm Hg for diabetics) was achieved in 72.7% (95% confidence interval [CI], 68.6-76.9) of patients receiving amlodipine/valsartan 5/160 mg and in 74.8% (95% CI, 70.8-78.9) receiving amlodipine/valsartan 10/160 mg. Incremental reductions from baseline in mean sitting systolic and diastolic BP were significantly greater with the higher dose (20.0+/-0.7 vs 17.5+/-0.7 mm Hg; P=.0003 and 11.6+/-0.4 vs 10.4+/-0.4 mm Hg; P=.0046). Incremental BP reductions were also achieved with both regimens irrespective of previous monotherapy, hypertension severity, diabetic status, body mass index, and age. Peripheral edema was the most frequent adverse event. These results provide support for the BP-lowering benefits of complementary antihypertensive therapy with amlodipine and valsartan in patients with hypertension uncontrolled by previous monotherapy. | | Language | eng | | Pub Type(s) | Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
| | PubMed ID | 18326958 |
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