| Title | Effects of switching from topical beta-blockers to latanoprost on intraocular pressure in patients with normal-tension glaucoma. | | Author(s) | Ikeda Y, Mori K, Ishibashi T, Naruse S, Nakajima N, Kinoshita S | | Institution | Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan. yikeda@ophth.kpu-m.ac.jp | | Source | J Ocul Pharmacol Ther 2008 Apr; 24(2):230-4. | | MeSH | Adrenergic beta-Antagonists
Antihypertensive Agents
Betaxolol
Carteolol
Female
Glaucoma, Open-Angle
Humans
Intraocular Pressure
Male
Middle Aged
Ophthalmic Solutions
Propanolamines
Prospective Studies
Prostaglandins F, Synthetic
Time Factors
| | Abstract | AIMS: The effects of switching from topical beta-blockers (beta) to latanoprost (LA) on intraocular pressure (IOP) and IOP-reduction rate (IOP-RR) in patients with normal-tension glaucoma (NTG) were investigated.
SUBJECTS AND METHODS: Sixty (60) NTG patients (60 eyes) were divided into three equal groups receiving carteolol hydrochloride (group A), nipradilol (group B), and betaxolol hydrochloride (group C) twice-daily for 3 months. The drugs were changed to topical LA administered once-daily for the next 3 months.
RESULTS: Baseline IOP was 14.4 +/- 0.9, 14.6 +/- 0.6, and 14.6 +/- 0.9 mmHg in groups A, B, and C, respectively. At 3 months, IOP was 12.4 +/- 0.6, 13.4 +/- 0.6, and 12.9 +/- 0.8 mmHg and 10.5 +/- 0.5, 11.1 +/- 0.8, and 11.7 +/- 0.8 mmHg at 6 months in groups A, B, and C, respectively. At 3 months, IOP-RR was 10.4 +/- 5.5, 9.5 +/- 2.6, and 10.8 +/- 4.7% and 24.1 +/- 4.3, 22.9 +/- 5.9, and 19.4 +/- 3.8% at 6 months in groups A, B, and C, respectively. The groups did not significantly differ in the first 3 months regarding IOP and IOP-RR. Switching to LA significantly decreased IOP and increased IOP-RR in all groups.
CONCLUSION: In NTG patients, LA reduced IOP more effectively than the beta tested. | | Language | eng | | Pub Type(s) | Comparative Study
Controlled Clinical Trial
Journal Article
| | PubMed ID | 18341431 |
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