| Title | Effects of chitosan-coated pressed calcium sulfate pellet combined with recombinant human bone morphogenetic protein 2 on restoration of segmental bone defect. | | Author(s) | Cui X, Zhang B, Wang Y, Gao Y | | Institution | Department of Orthopedics, General Hospital of Chinese People's Liberation Army, Beijing, China. | | Source | J Craniofac Surg 2008 Mar; 19(2):459-65. | | Abstract | A chitosan-coated pressed calcium sulfate pellet combined with recombinant human bone morphogenetic protein 2 (rhBMP-2) has been developed with increased compressive strength and osteoinduction, but with a resorption profile only slightly slower than uncoated pellet. A radial segmental defect model of rabbit was used to study the restoration effect on defect treated with chitosan-coated pressed calcium sulfate pellet combined with rhBMP-2, coated pressed calcium sulfate pellet, and uncoated pressed calcium sulfate pellet. Nothing was implanted in the control group. After 4, 8, and 12 weeks, the results indicated that coated pressed calcium sulfate pellet combined with rhBMP-2 and coated pressed calcium sulfate pellet facilitated new bone formation on defected bone and that particularly the former was more effective than the latter. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18362727 |
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