| Title | Complement Component C1q and Anti-C1q Antibodies in Theory and in Clinical Practice. | | Author(s) | Potlukova E, Kralikova P | | Institution | Third Clinic of Medicine, General Teaching Hospital, First Faculty of Medicine, Charles University, Prague, Czech Republic. | | Source | Scand J Immunol 2008 Mar 17. | | Abstract | The complement system is a major part of the innate immunity. The first component of the classical pathway of complement activation, C1q, plays a crucial role in the clearance of immune complexes and apoptotic bodies from the organism. Autoantibodies against C1q (anti-C1q) have been found in a number of autoimmune and infectious diseases. They have been best described in patients with systemic lupus erythematosus, where they are thought to play a pathogenic role in lupus nephritis (LN). Their high negative predictive value for the occurrence of active proliferative LN, as well as their possible ability to indicate a renal flare as soon as 6 months in advance, have rendered anti-C1q antibodies a novel non-invasive tool in the detection of active LN. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18363591 |
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