| Title | Searching for the cause of Kawasaki disease - cytoplasmic inclusion bodies provide new insight. | | Author(s) | Rowley AH, Baker SC, Orenstein JM, Shulman ST | | Institution | Anne H. Rowley and Stanford T. Shulman are at the Departments of Pediatrics and Microbiology/Immunology, Northwestern University Feinberg School of Medicine, The Center for Kawasaki Disease, The Children's Memorial Hospital, Chicago, 60611 Illinois, USA. | | Source | Nat Rev Microbiol 2008 Mar 26. | | Abstract | Kawasaki disease (KD) has emerged as the most common cause of acquired heart disease in children in the developed world. The cause of KD remains unknown, although an as-yet unidentified infectious agent might be responsible. By determining the causative agent, we can improve diagnosis, therapy and prevention of KD. Recently, identification of an antigen-driven IgA response that was directed at cytoplasmic inclusion bodies in KD tissues has provided new insights that could unlock the mysteries of KD. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18364728 |
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