The effects of mineral trioxide aggregates on cytokine production by mouse pulp tissue. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] Journal article

Title	The effects of mineral trioxide aggregates on cytokine production by mouse pulp tissue.
Author(s)	Silva MJ, Vieira LQ, Sobrinho AP
Institution	Department of Biochemistry and Immunology, Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Source	Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008 May; 105(5):e70-6.
MeSH	Aluminum Compounds Animals Calcium Compounds Chemokine CCL5 Cytokines Dental Pulp Dental Pulp Capping Down-Regulation Drug Combinations Gene Expression Inflammation Mediators Interferon Type II Interleukin-1 Mice Mice, Inbred C57BL Oxides Pulpotomy Reverse Transcriptase Polymerase Chain Reaction Root Canal Filling Materials Silicates Tumor Necrosis Factor-alpha
Abstract	OBJECTIVE: The objective of this study was to determine the effect of MTA on the expression of cytokines in mouse pulp tissue. STUDY DESIGN: Pulp tissue was exposed to MTA, and the expression of CCL5/RANTES, CCL2/MCP1, IL-1alpha, IFN-gamma, TNF-alpha, IL-4, and IL-6 was evaluated by RT-PCR at 10 and 20 days after exposure. Control groups were not exposed to MTA. RESULTS: We found no detectable expression of CCL2, IL-4, and IL-6 in the tissue from either group, while TNF-alpha was expressed at high levels 20 days after exposure (P < .05). CCL5 and IL-1alpha mRNA expression was lower in the MTA-treated group 10 days after treatment (P < .05). At 20 days after the surgical procedure, IFN-gamma mRNA expression was also lower in the MTA-treated group (P < .05). CONCLUSIONS: These findings suggest that MTA down-regulates the inflammatory cytokines CCL5, IL-1alpha and IFN-gamma and may have an anti-inflammatory effect.
Language	eng
Pub Type(s)	Journal Article Research Support, Non-U.S. Gov't
PubMed ID	18442739

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