A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. Science (New York, N.Y.) [Science] Journal article | | Title | A haptoglobin-hemoglobin receptor conveys innate immunity to Trypanosoma brucei in humans. | | Author(s) | Vanhollebeke B, De Muylder G, Nielsen MJ, Pays A, Tebabi P, Dieu M, Raes M, Moestrup SK, Pays E | | Institution | Laboratory of Molecular Parasitology, Institute for Molecular Biology and Medicine, Université Libre de Bruxelles, 12 rue des Profs Jeener et Brachet, B6041 Gosselies, Belgium. | | Source | Science 2008 May 2; 320(5876):677-81. | | MeSH | Amino Acid Sequence
Animals
Haptoglobins
Hemoglobins
Humans
Immunity, Natural
Lipoproteins, HDL
Mice
Mice, Inbred Strains
Molecular Sequence Data
Receptors, Cell Surface
Trypanosoma brucei brucei
| | Abstract | The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein L-I, a component of human high-density lipoprotein (HDL) particles that are also characterized by the presence of haptoglobin-related protein. We report that this process is mediated by a parasite glycoprotein receptor, which binds the haptoglobin-hemoglobin complex with high affinity for the uptake and incorporation of heme into intracellular hemoproteins. In mice, this receptor was required for optimal parasite growth and the resistance of parasites to the oxidative burst by host macrophages. In humans, the trypanosome receptor also recognized the complex between hemoglobin and haptoglobin-related protein, which explains its ability to capture trypanolytic HDLs. Thus, in humans the presence of haptoglobin-related protein has diverted the function of the trypanosome haptoglobin-hemoglobin receptor to elicit innate host immunity against the parasite. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18451305 |
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