Vestergaard P, Rejnmark L, Mosekilde L [Osteoporosis and fractures associated with drugs.] [JOURNAL ARTICLE] Ugeskr Laeger 2008 Apr 28; 170(18):1550-1555.
Drugs can affect the skeleton in different ways. Antiepileptic drugs were not associated with any major fracture risk. Lithium was associated with a decreased fracture risk. Insulin, sulphonylureas and metformin were associated with a decreased risk, whereas glitazones were associated with an increased risk. Blood pressure lowering drugs, thiazide diuretics and nitroglycerin were associated with a decreased risk of fractures, whereas amiodarone and loop diuretics were associated with an increased risk. Pain medication varied from no effect to an increased fracture risk.
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