| Title | Inflammatory proteins and muscle strength in adolescents: the Avena study. | | Author(s) | Ruiz JR, Ortega FB, Wärnberg J, Moreno LA, Carrero JJ, Gonzalez-Gross M, Marcos A, Gutierrez A, Sjöström M | | Institution | Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Huddinge, Sweden. ruizj@ugr.es | | Source | Arch Pediatr Adolesc Med 2008 May; 162(5):462-8. | | MeSH | Adolescent
C-Reactive Protein
Ceruloplasmin
Complement C3
Complement C4
Cross-Sectional Studies
Female
Humans
Immunoproteins
Male
Muscle Strength
Overweight
Physical Fitness
Prealbumin
Regression Analysis
| | Abstract | OBJECTIVES: To examine the associations between inflammatory proteins and muscle strength and to determine whether this association varies between overweight and nonoverweight adolescents.
DESIGN: Cross-sectional study.
PARTICIPANTS: A total of 416 Spanish adolescents (230 boys and 186 girls) aged 13 to 18(1/2) years. MAIN EXPOSURES: Muscle strength score was computed as the mean of the handgrip and standing broad jump standardized values. The adolescents were categorized as overweight (including obese) or nonoverweight according to body mass index. Body fat and fat-free mass were derived from skinfold thickness.
OUTCOME MEASURES: C-reactive protein, complement factors C3 and C4, ceruloplasmin, and prealbumin levels.
RESULTS: The results of the regression analysis showed that C-reactive protein, C3, and ceruloplasmin were negatively associated with muscle strength after controlling for sex, age, pubertal status, weight, height, socioeconomic status, and cardiorespiratory fitness. Moreover, C-reactive protein and prealbumin levels were associated with muscle strength in overweight adolescents after controlling for potential confounders, including body fat and fat-free mass.
CONCLUSIONS: Low-grade inflammation is negatively associated with muscle strength in adolescents. The patterns of these associations seem more relevant in overweight adolescents, suggesting that having high levels of muscle strength may counteract the negative consequences ascribed to body fat. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18458193 |
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