| Title | Dietary Protein and Bone Health: Roles of Amino Acid-Sensing Receptors in the Control of Calcium Metabolism and Bone Homeostasis. | | Author(s) | Conigrave AD, Brown EM, Rizzoli R | | Institution | School of Molecular and Microbial Biosciences, University of Sydney, NSW 2006, Australia; email: a.conigrave@mmb.usyd.edu.au. | | Source | Annu Rev Nutr 2008 May 8. | | Abstract | In this article, we review the evidence that dietary protein has a positive influence on bone health, reduces hip fracture risk, and promotes postfracture recovery, and we consider the molecular, cellular, and endocrine bases of the interactions that link protein and calcium metabolism, including IGF-1 and PTH. In addition, we consider the roles of amino acid-sensing mechanisms in coupling dietary protein intake to metabolic change as well as the central role of calcium-sensing receptors (CaRs) in the control of calcium metabolism. Finally, we consider how recently identified broad-spectrum amino acid-sensing receptors from class 3 of the G-protein coupled receptor superfamily including, remarkably, the CaR itself may contribute to the impact of dietary protein on bone. Expected final online publication date for the Annual Review of Nutrition Volume 28 is July 17, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18466091 |
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