| Title | The effect of achiral calixarenes on chiral separation of propranolol-HCl and brompheniramine maleate in capillary electrophoresis using cyclodextrin as chiral selector. |
| Author(s) | Hashem H, Kinzig M, Jira T |
| Institution | Institute of Pharmacy, Ernst-Moritz-Arndt-University Greifswald, Germany. |
| Source | Pharmazie 2008 Apr; 63(4):256-62. |
| Abstract | In this study we have examined the effect of achiral water soluble p-sulfonatocalixarenes (SCX[n]) on chiral separation propranolol-HCl and brompheniramine maleate. Several cyclodextrins (CDs) and cyclodextrin derivatives were examined as chiral selectors applying complete filling technique (CFT) accompanied with the partial filling technique PFT of (SCX[n]) as achiral modifier. Only with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) chiral separation could be achieved. The effect of the organic modifier on these chiral separations was examined. The results indicate that at pH 4.65, the use of HP-beta-CD (CFT) alone could not initiate chiral separations of both analytes and these chiral separations could be induced using HP-beta-CD (CFT) followed by SCX[n]/HP-beta-CD (PFT). |
| Language | eng |
| Pub Type(s) | Journal Article
|
| PubMed ID | 18468383 |
