Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. The American journal of clinical nutrition [Am J Clin Nutr] Journal article | | Title | Plasma pyridoxal 5'-phosphate in the US population: the National Health and Nutrition Examination Survey, 2003-2004. | | Author(s) | Morris MS, Picciano MF, Jacques PF, Selhub J | | Institution | Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA. martha.morris@tufts.edu | | Source | Am J Clin Nutr 2008 May; 87(5):1446-54. | | MeSH | Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biological Markers
Child
Child, Preschool
Diet
Dietary Supplements
Female
Homocysteine
Humans
Infant
Male
Middle Aged
Nutrition Policy
Nutrition Surveys
Nutritional Requirements
Nutritional Status
Pyridoxal Phosphate
Sex Factors
United States
Vitamin B 6
Vitamin B 6 Deficiency
| | Abstract | BACKGROUND: No large-scale, population-based study has considered the descriptive epidemiology of vitamin B-6 status with use of plasma pyridoxal 5'-phosphate (PLP), the indicator of vitamin B-6 adequacy used to set the current Recommended Dietary Allowance, which is < or = 2 mg/d for all subgroups.
OBJECTIVES: We sought to examine the epidemiology of vitamin B-6 status in the US population.
METHODS: In > 6000 participants aged > or = 1 y in the National Health and Nutrition Examination Survey (2003-2004), we considered relations between plasma PLP and various subject characteristics and examined trends in plasma PLP and homocysteine with vitamin B-6 intake, both overall and in selected subgroups.
RESULTS: In males, plasma PLP decreased with age after adolescence only in nonusers of supplemental vitamin B-6. Regardless of supplement use, plasma PLP concentrations of women of childbearing age were significantly lower than those of comparably aged men, and most oral contraceptive users had plasma PLP < 20 nmol/L. The prevalence of low plasma PLP was significantly > 3% at vitamin B-6 intakes from 2 to 2.9 mg/d in all subgroups and at intakes from 3 to 4.9 mg/d in smokers, the elderly, non-Hispanic blacks, and current and former oral contraceptive users. Intakes from 3 to 4.9 mg/d compared with < 2 mg/d were associated with significant protection from low plasma PLP in most subgroups and from hyperhomocysteinemia in the elderly.
CONCLUSIONS: Vitamin B-6 intakes of 3 to 4.9 mg/d appear consistent with the definition of a Recommended Dietary Allowance for most Americans. However, at that intake level, substantial proportions of some population subgroups may not meet accepted criteria for adequate vitamin B-6 status. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
| | PubMed ID | 18469270 |
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