| Title | The synergistic effect of 1-hydroxyanthraquinone on methylazoxymethanol acetate-induced carcinogenesis in rats. | | Author(s) | Mori Y, Yoshimi N, Iwata H, Tanaka T, Mori H | | Institution | First Department of Pathology, Gifu University School of Medicine, Japan. | | Source | Carcinogenesis 1991 Feb; 12(2):335-8. | | MeSH | Administration, Oral
Animals
Anthraquinones
Carcinoma, Hepatocellular
Drug Synergism
Female
Injections, Intraperitoneal
Intestinal Neoplasms
Liver
Male
Methylazoxymethanol Acetate
Neoplasms, Experimental
Rats
Rats, Inbred Strains
| | Abstract | The synergistic potential of 1-hydroxyanthraquinone (1-HA) on methylazoxymethanol (MAM) acetate-induced carcinogenesis was investigated in rats. A total of 154 inbred ACI/N rats (73 males and 81 females), six weeks old at the start of the experiment, were divided into four groups: group 1 was given i.p. injections of MAM acetate (25 mg/kg body wt), once per week for 2 weeks and then fed the diet containing 1% 1-HA for 42 weeks; group 2 received MAM acetate and was kept on the basal diet alone; group 3 was given 1-HA containing diet alone as for group 1; group 4 was treated as a control. At the termination of the experiment, the carcinogenic effect of MAM acetate and 1-HA in the large bowel or liver exceeded the sum of effects when given alone, indicating that the two chemicals act synergistically in the carcinogenesis of these organs. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 1847322 |
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