Braumann C, Tangermann J, Jacobi CA, Müller JM, Dubiel W
Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. [Journal Article, Review]
Mini Rev Med Chem 2008 May; 8(5):421-8.
Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis.
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