Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini reviews in medicinal chemistry [Mini Rev Med Chem] Journal article | | Title | Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. | | Author(s) | Braumann C, Tangermann J, Jacobi CA, Müller JM, Dubiel W | | Institution | Department of General, Visceral, Vascular and Thoracic Surgery, - Universitätsmedizin Berlin, Monbijoustrasse 2, 10117 Berlin, Germany. | | Source | Mini Rev Med Chem 2008 May; 8(5):421-8. | | MeSH | Angiogenesis Inhibitors
Animals
Antineoplastic Agents
Curcumin
Drug Screening Assays, Antitumor
Emodin
Humans
Models, Molecular
Multiprotein Complexes
Neoplasms
Peptide Hydrolases
Protein Kinase Inhibitors
Structure-Activity Relationship
Taurine
Thiadiazines
| | Abstract | Preclinical studies revealed that curcumin, the yellow curry pigment, emodin, a compound derived from grapes, and taurolidine, derived from a biogenic amino acid, and some of their structural homologs possess anti-angiogenic and cancer chemopreventive properties. Whereas curcumin and emodin can act via inhibition of COP9 signalosome-associated kinases, taurolidine blocks protein biosynthesis. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 18473931 |
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