| Title | No gene copy number changes in Dupuytren's contracture by array comparative genomic hybridization. | | Author(s) | Kaur S, Forsman M, Ryhänen J, Knuutila S, Larramendy ML | | Institution | Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and University Central Hospital, POB 21 (Haartmaninkatu 3), Helsinki 00014, Finland. | | Source | Cancer Genet Cytogenet 2008 May; 183(1):6-8. | | Abstract | Dupuytren's contracture (DC), a benign disease of unknown origin, is characterized by abnormal fibroblast proliferation and matrix deposition within the palmar and plantar faciae, causing contracture of the digits. Conventional cytogenetic studies of cultured fibroblast cells from DC nodules have revealed nonrecurrent, but usually normal, clonal (mainly +7, +8, and -Y, plus structural changes) and sporadic (nonclonal) numerical/structural rearrangements. No unique cytogenetic features of DC are known so far. We used 44K oligonucleotide-based array comparative genomic hybridization to obtain a wide pattern of chromosomal imbalances in 18 patients with DC. The genome-wide analysis revealed no changes of DNA copy number sequences. Accordingly, gene amplifications or deletions are apparently not involved in the progression of abnormal fibroblast proliferation and matrix deposition that lead to DC. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18474290 |
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