| Title | Distinct evolution of calcium channel antibody types in Lambert-Eaton myasthenic syndrome. | | Author(s) | Martin-Moutot N, De Haro L, Seagar M | | Institution | INSERM, U641, Marseille F-13000, France; Université de la Mediterranée-Aix Marseille 2, Faculté de médecine, IFR 11, Bd P. Dramard, Marseille F-13000, France. | | Source | J Neuroimmunol 2008 May 10. | | Abstract | To determine whether titers of anti-P/Q type and anti-N type calcium channel antibodies provide distinct information, both types of assay were performed during follow-up of 7 patients with Lambert-Eaton myasthenic syndrome (LEMS). In 4 patients with both antibody responses, titers evolved independently and often in an inverse relationship. Two patients with squamous cell lung carcinoma (SqCLC) produced anti-N type channel antibodies, but no detectable anti-P/Q channel responses. These results suggest that anti-N channel autoantibodies constitute an immune response distinct from the anti-P/Q type channel specificity and can also correlate with clinical evolution. Consequently combined assays may provide more comprehensive information during follow-up of LEMS. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18474401 |
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