Kirkness CJ, Burr RL, Cain KC, Newell DW, Mitchell PH
The impact of a highly visible display of cerebral perfusion pressure on outcome in individuals with cerebral aneurysms. [Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural]
Heart Lung 2008 May-Jun; 37(3):227-37.
BACKGROUND: Nurses' ability to rapidly detect decreases in cerebral perfusion pressure (CPP), which may contribute to secondary brain injury, may be limited by poor visibility of CPP displays.
OBJECTIVE: To evaluate the impact of a highly visible CPP display on the functional outcome in individuals with cerebral aneurysms.
METHODS: Patients with cerebral aneurysms (n = 100) who underwent continuous CPP monitoring were enrolled and randomized to beds with or without the additional CPP display. Six-month outcome was assessed.
RESULTS: Functional outcome was not significantly different between control and intervention groups after controlling for initial neurologic condition (odds ratio .904, 95% confidence interval 0.317 to 2.573). However, greater time below CPP thresholds (55 to 70 mm Hg) was significantly associated with poorer outcome (P = .005 to .010).
CONCLUSIONS: Although the enhanced CPP display was not associated with significantly better outcome, longer periods of CPP below set levels were associated with poorer outcome.
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