| Title | Systemic Iron Homeostasis and the Iron-Responsive Element/Iron-Regulatory Protein (IRE/IRP) Regulatory Network. | | Author(s) | Muckenthaler MU, Galy B, Hentze MW | | Institution | Molecular Medicine Partnership Unit, Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, D-69120 Heidelberg, Germany. | | Source | Annu Rev Nutr 2008 May 19. | | Abstract | The regulation and maintenance of systemic iron homeostasis is critical to human health. Iron overload and deficiency diseases belong to the most common nutrition-related pathologies across the globe. It is now well appreciated that the hormonal hepcidin/ferroportin system plays an important regulatory role for systemic iron metabolism. We review recent data that uncover the importance of the cellular iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network in systemic iron homeostasis. We also discuss how the IRE/IRP regulatory system communicates with the hepcidin/ferroportin system to connect the control networks for systemic and cellular iron balance. Expected final online publication date for the Annual Review of Nutrition Volume 28 is July 17, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18489257 |
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