The Influence of Pregnancy and Gender on Perivascular Innervation of Rat Posterior Cerebral Arteries. Reproductive sciences (Thousand Oaks, Calif.) [Reprod Sci] Journal article | | Title | The Influence of Pregnancy and Gender on Perivascular Innervation of Rat Posterior Cerebral Arteries. | | Author(s) | Aukes AM, Bishop N, Godfrey J, Cipolla MJ | | Institution | University of Vermont, Departments of Neurology, Obstetrics and Gynecology, and Pharmacology, Burlington, University of Groningen, School of Behavioral and Cognitive Neurosciences, and University Medical Center Groningen, Department of Obstetrics and Gynecology, Groningen, the Netherlands. | | Source | Reprod Sci 2008 Apr; 15(4):411-419. | | Abstract | The authors investigated the influence of pregnancy and gender on the density of trigeminal and sympathetic perivascular nerves in posterior cerebral arteries (PCA) and the reactivity to norepinephrine and calcitonin gene-related peptide (CGRP). PCAs were isolated from nonpregnant, late-pregnant, postpartum, and male rats, mounted and pressurized on an arteriograph chamber to obtain concentration-response curves to norepinephrine and CGRP. Arteries were immunostained for CGRP-, tyrosine hydroxylase-, and protein gene product 9.5 (PGP 9.5)-containing perivascular nerves, and nerve density was determined morphologically. Pregnancy had a trophic effect on trigeminal perivascular innervation (P < .01 vs male); however, this was not accompanied by a change in reactivity to CGRP. Sympathetic and PGP 9.5 nerve densities were not altered by pregnancy or gender, and there were no differences in reactivity to norepinephrine. Together, these results suggest that the increase in trigeminal innervation during pregnancy is more related to nociception than in controlling resting cerebral blood flow. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18497348 |
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