| Title | Interleukin-2 immediate type hypersensitivity? | | Author(s) | Caucig P, Lescau S, Knop J, Maurer M, von Stebut E | | Institution | Department of Dermatology, Johannes Gutenberg University, Mainz, Germany. | | Source | J Dtsch Dermatol Ges 2008 May 21. | | Abstract | Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18498378 |
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