Herrmann J, Soares SM, Lerman LO, Lerman A
Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease. [Journal Article, Research Support, N.I.H., Extramural]
J Am Coll Cardiol 2008 May 27; 51(21):2003-10.
Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease.
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