| Title | Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease. | | Author(s) | Herrmann J, Soares SM, Lerman LO, Lerman A | | Institution | Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. joerg@mayo.edu | | Source | J Am Coll Cardiol 2008 May 27; 51(21):2003-10. | | Abstract | Misfolded or damaged proteins are recognized intracellularly by protein quality mechanisms. These include chaperones and the ubiquitin-proteasome system, which aim at restoration of protein function and protein removal, respectively. A number of studies have outlined the functional significance of the ubiquitin-proteasome system for the heart and, as of recently, for the vascular system. This review summarizes these recent findings with a focus on atherosclerosis. In particular, this paper reflects on the viewpoint of atherosclerosis as a protein quality disease. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
| | PubMed ID | 18498952 |
|
