| Title | Beneficial effect of Embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. | | Author(s) | Bhandari U, Jain N, Ansari MN, Pillai KK | | Institution | Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110062, India. uma_bora@hotmail.com | | Source | Fitoterapia 2008 Jul; 79(5):351-5. | | MeSH | Animals
Blood Glucose
Blood Pressure
Diabetes Mellitus, Experimental
Embelia
Ethanol
Female
Heart Rate
Hemoglobin A, Glycosylated
Hypoglycemic Agents
Male
Plant Extracts
Rats
Rats, Wistar
Streptozocin
| | Abstract | Embelia ribes (common name, Vidanga) is extensively used in traditional system of medicine for treatment of various disorders. It is described in Ayurveda, as a powerful anthelmintic, antifertility and antihyperlipidemic agent. The present study was undertaken to investigate modulatory effect of 6 weeks' chronic oral administration of E. ribes ethanolic extract on diabetes mellitus induced by a diabetogen, streptozotocin (STZ) with special reference to changes in glucose levels, glycated haemoglobin status and cardiac toxicity. STZ treatment (40 mg/kg iv) resulted in significant increase in blood glucose levels, glycated haemoglobin levels, heart rate (HR) and systolic blood pressure (SBP). Oral administration of E. ribes ethanolic extract in dose of 100 mg/kg and 200 mg/kg significantly reduced the levels of blood glucose, glycated haemoglobin, heart rate (HR) and systolic blood pressure (SBP) in animals when compared with diabetic rats. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
| | PubMed ID | 18508204 |
|
