McDougle CJ, Stigler KA, Erickson CA, Posey DJ
Atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders. [Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review]
J Clin Psychiatry 2008.:15-20.
Atypical antipsychotics are emerging as the first-line pharmacologic treatment for irritability (i.e., aggression, self-injurious behavior, and severe tantrums) in children and adolescents with autistic and other pervasive developmental disorders. Results from placebo-controlled and open-label studies of clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole in this subject population are reviewed. Additional placebo-controlled trials and studies of longer-term safety and tolerability are needed.
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