Dery M, Bausch DG
A DNA vaccine for the prevention of Ebola virus infection. [Journal Article]
Curr Opin Mol Ther 2008 Jun; 10(3):285-93.
The NIH and Vical Inc are developing an intramuscular needle-free DNA vaccine containing plasmids encoding the envelope glycoprotein of Ebola virus (EBOV) from the Sudan and Zaire strains, and the nucleoprotein of EBOV Zaire strain. A phase I clinical trial demonstrated a good safety profile, with most adverse events limited to the site of injection and largely attributable to the delivery.
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