| Title | T(H)2 adjuvants: implications for food allergy. | | Author(s) | Berin MC, Shreffler WG | | Institution | Department of Pediatrics, Division of Allergy and Immunology, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, New York, NY 10029, USA. | | Source | J Allergy Clin Immunol 2008 Jun; 121(6):1311-20; quiz 1321-2. | | MeSH | Adjuvants, Immunologic
Allergens
Animals
Antigen Presentation
Cell Differentiation
Food Hypersensitivity
Humans
Lymphocyte Activation
T-Lymphocyte Subsets
Th2 Cells
| | Abstract | A persistent question for immunologists studying allergic disease has been to define the characteristics of a molecule that make it allergenic. There has been substantial progress elucidating mechanisms of innate priming of T(H)2 immunity in the past several years. These accumulating data demonstrate that T(H)2 immunity is actively induced by an array of molecules, many of which were first discovered in the context of antihelminthic immune responses. Similar intrinsic or associated activities are now known to account for the T(H)2 immunogenicity of some allergens, and may prove to play a role for many more. In this review, we discuss what has been discovered regarding molecules that induce innate immune activation and the pathways that promote T(H)2-polarized immune responses generally, and specifically what role these mechanisms may play in food allergy from models of food allergy and the study of T(H)2 gastrointestinal adjuvants. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Review
| | PubMed ID | 18539190 |
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