| Title | Melanoma stem cells: the dark seed of melanoma. | | Author(s) | Zabierowski SE, Herlyn M | | Institution | The Wistar Institute, 3601 Spruce St, Philadelphia, PA 19104, USA. | | Source | J Clin Oncol 2008 Jun 10; 26(17):2890-4. | | MeSH | Animals
Antigens, CD
Antigens, CD20
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Cell Separation
Flow Cytometry
Glycoproteins
Humans
Melanoma
Neoplastic Stem Cells
Peptides
Spheroids, Cellular
Staining and Labeling
Tumor Cells, Cultured
Tumor Markers, Biological
| | Abstract | Cells with stem-cell markers and features have recently been identified in melanoma tissues and cell lines. Melanoma stem-like cells possess many traits of tumor-initiating or tumor stem cells including self-renewal capacity, high tumorigenicity, and differentiation into various mesenchymal lineages, including melanocytic cells. Four subpopulations of melanoma-initiating cells have been distinguished: CD20(+), CD133(+), label-retaining or slow-cycling cells, and side-population cells with high efflux activities. Whether these are distinct or overlapping populations is currently under investigation. Ongoing studies are dissecting and characterizing the hierarchy of these subpopulations within a malignant lesion. Understanding these and the dynamics of clonal dominance will aid in the development of novel therapeutic strategies. | | Language | eng | | Pub Type(s) | Journal Article
Review
| | PubMed ID | 18539969 |
|
