| Title | [Importance of the formulation for a chronopharmacologically optimised way of pain therapy. Results of a comparative bioavailability study of tramadol extended-release capsules after single-dose evening versus morning administration] | | Author(s) | Warnke A, Schug B, Vanderbist F, Blume H | | Institution | SocraTec R&D GmbH, Oberursel | | Source | MMW Fortschr Med 2008 Apr 10.:36-42. | | Abstract | Objective of this study was to investigate the rate and extent of tramadol bioavailability following evening versus morning administration.
METHODS: The study was performed following an open, randomised, cross-over study-design. 18 male and female volunteers were enrolled into the study and treated with 200 mg tramadol extended-release capsules (T-long), which were to be taken either in the morning or in the evening.
RESULTS: Plasma concentration versus time profiles obtained after morning and evening administration were almost superimposable for both, tramadol and its active metabolite. Maximum exposure of tramadol and O-desmethyltramadol (geometric means of c(max)-values) as well as extent of exposure (geometric means of AUC(0-48)-values) were comparable after morning and eveningadministration.
CONCLUSIONS: Time-point of administration does not have any relevant impact on the rate and extent of absorption in the investigated dosage form. Thus, time-point of administration may be adjusted to the patient's need in a chronopharmacologically optimised way for pain therapy. | | Language | ger | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 18540331 |
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