| Title | Open-label study to assess the safety and efficacy of imiquimod 5% cream applied once daily three times per week in cycles for treatment of actinic keratoses on the head. | | Author(s) | Rivers JK, Rosoph L, Provost N, Bissonnette R | | Source | J Cutan Med Surg 2008 May-Jun; 12(3):97-101. | | Abstract | BACKGROUND: Local skin reactions are common during imiquimod treatment of actinic keratosis (AK). Cyclical application of imiquimod may improve tolerability while maintaining efficacy.
OBJECTIVE: To assess the tolerability of imiquimod and clearance rate of AK lesions after imiquimod application.
METHODS: Imiquimod 5% cream was administered three times per week for 4 weeks followed by 4 weeks of rest (cycle 1) to AK lesions on the head. If AK lesions remained visible at the end of cycle 1, a second treatment cycle was instituted.
RESULTS: Fifty percent (30 of 60) of patients experienced complete clearance of AK lesions, and 75% (30 of 40) of patients experienced partial clearance of AK lesions after imiquimod treatment at the end of cycle 2. Moreover, 77% of patients who achieved complete clearance had no visible AK lesions 12 weeks post-treatment. Imiquimod was well tolerated.
CONCLUSION: Imiquimod cycle therapy may be a safe and effective treatment option for AK lesions. | | Language | eng | | Pub Type(s) | Journal Article
| | PubMed ID | 18544290 |
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