| Title | [Whipple's disease.] | | Author(s) | Eriksen R, Westre B, Bergh K, Qvigstad G | | Institution | Gastroenterologisk seksjon Medisinsk avdeling. ragnar.eriksen@helse-sunnmore.no. | | Source | Tidsskr Nor Laegeforen 2008 Jun 12; 128(12):1406-9. | | Abstract | BACKGROUND: Whipple's disease is a rare infectious disease. This review describes the clinical picture, diagnostic aspects and treatment options.
MATERIAL AND METHODS: Based on a clinical case, a literature study was performed by searching PubMed (unlimited) with the words "whipples disease" combined with " TROPHERYMA WHIPPELII: " (118 hits) and " TROPHERYMA WHIPPLEI:" (65 hits). Titles and abstracts were used to identify other relevant articles.
RESULTS AND
INTERPRETATION: Whipple's disease may affect several organ systems and thus causes a wide range of symptoms. The most common ones are weight loss, abdominal pain, diarrhoea and arthralgia. The diagnosis is based on PAS-POSITIVE MATERIAL: in duodenal biopsies and identification of gene fragments from the bacterium TROPHERYMA WHIPPLEI:. Presence of the bacterium may be confirmed by sensitive polymerase chain reaction assays. Left without treatment the disease may be lethal. Proper antibiotic treatment is imperative to heal the disease. | | Language | nor | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 18552903 |
|
