Santin AD, Bellone S, Roman JJ, McKenney JK, Pecorelli S
Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu. [JOURNAL ARTICLE]
Int J Gynaecol Obstet 2008 Jun 12.
OBJECTIVE: To study the effect of trastuzumab in patients with progressive or recurrent metastatic endometrial carcinoma shown by immunohistochemistry to overexpress the HER2/neu receptor.
METHODS: Disease progression was examined in 2 patients who met the study criteria, had c-erbB2 gene amplification by fluorescence in situ hybridization, and were treated with trastuzumab following radiation treatment and/or salvage chemotherapy.
RESULTS: The clinical responses to trastuzumab as a single agent or in combination with chemotherapy were confirmed in both patients by serial CT scans and serum CA-125 evaluations. These patients with progressive or recurrent metastatic disease experienced relief from their symptoms and prolonged survival with no significant toxicity observed.
CONCLUSION: Trastuzumab may be a viable therapeutic option as single agent or in combination with chemotherapy in patients with advanced, recurrent, and/or metastatic endometrial carcinomas overexpressing HER2/neu.
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