| Title | Systemic endocrine instigation of indolent tumor growth requires osteopontin. | | Author(s) | McAllister SS, Gifford AM, Greiner AL, Kelleher SP, Saelzler MP, Ince TA, Reinhardt F, Harris LN, Hylander BL, Repasky EA, Weinberg RA | | Institution | Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. | | Source | Cell 2008 Jun 13; 133(6):994-1005. | | MeSH | Adenocarcinoma
Animals
Bone Marrow Cells
Breast Neoplasms
Cell Division
Cell Line, Tumor
Cell Movement
Colonic Neoplasms
Humans
Mice
Mice, Nude
Neoplasm Metastasis
Neoplasm Transplantation
Osteopontin
Transplantation, Heterologous
| | Abstract | The effects of primary tumors on the host systemic environment and resulting contributions of the host to tumor growth are poorly understood. Here, we find that human breast carcinomas instigate the growth of otherwise-indolent tumor cells, micrometastases, and human tumor surgical specimens located at distant anatomical sites. This systemic instigation is accompanied by incorporation of bone-marrow cells (BMCs) into the stroma of the distant, once-indolent tumors. We find that BMCs of hosts bearing instigating tumors are functionally activated prior to their mobilization; hence, when coinjected with indolent cells, these activated BMCs mimic the systemic effects imparted by instigating tumors. Secretion of osteopontin by instigating tumors is necessary for BMC activation and the subsequent outgrowth of the distant otherwise-indolent tumors. These results reveal that outgrowth of indolent tumors can be governed on a systemic level by endocrine factors released by certain instigating tumors, and hold important experimental and therapeutic implications. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
| | PubMed ID | 18555776 |
|
