VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science (New York, N.Y.) [Science] Journal article | | Title | VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. | | Author(s) | Bayram O, Krappmann S, Ni M, Bok JW, Helmstaedt K, Valerius O, Braus-Stromeyer S, Kwon NJ, Keller NP, Yu JH, Braus GH | | Institution | Institute of Microbiology and Genetics, Georg August University, D-37077 Göttingen, Germany. | | Source | Science 2008 Jun 13; 320(5882):1504-6. | | MeSH | Active Transport, Cell Nucleus
Aspergillus nidulans
Cell Nucleus
Cytoplasm
Darkness
Epigenesis, Genetic
Fungal Proteins
Gene Expression Regulation, Fungal
Light
Protein Binding
Protein Interaction Mapping
Recombinant Fusion Proteins
Spores, Fungal
Sterigmatocystin
| | Abstract | Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
| | PubMed ID | 18556559 |
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