| Title | Clinical and molecular characterisation of a prospectively collected cohort of children and adolescents with polycythemia vera. | | Author(s) | Cario H, Schwarz K, Herter JM, Komrska V, McMullin MF, Minkov M, Niemeyer C, Pospisilova D, Reinhard H, Debatin KM, Pahl HL | | Institution | Department of Paediatrics, University Hospital Ulm, Ulm, Germany. | | Source | Br J Haematol 2008 Jun 13. | | Abstract | The clinical, haematological, molecular and treatment data of eight paediatric patients with polycythemia vera (PV) were collected prospectively. One patient developed PV after treatment for large-cell anaplastic lymphoma. Budd-Chiari syndrome was diagnosed in two patients, necessitating orthotopic liver transplantation in one and transjugular portosystemic shunting in the other. The remaining patients presented with non-specific symptoms. Endogenous erythroid colonies were detected in all cases examined. The JAK2(V617F) mutation was found in six patients; two patients displayed JAK2 exon 12 mutations, including one novel mutation (JAK2(H538-K539delinsI)). CD177 (PRV-1) mRNA expression was increased in three of five patients tested. | | Language | ENG | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 18557746 |
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