| Title | Mechanisms underlying development of visual maps and receptive fields. | | Author(s) | Huberman AD, Feller MB, Chapman B | | Institution | Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA. adh1@stanford.edu | | Source | Annu Rev Neurosci 2008.:479-509. | | MeSH | Animals
Brain Mapping
Cell Differentiation
Growth Cones
Humans
Nerve Growth Factors
Retina
Synapses
Visual Cortex
Visual Fields
Visual Pathways
| | Abstract | Patterns of synaptic connections in the visual system are remarkably precise. These connections dictate the receptive field properties of individual visual neurons and ultimately determine the quality of visual perception. Spontaneous neural activity is necessary for the development of various receptive field properties and visual feature maps. In recent years, attention has shifted to understanding the mechanisms by which spontaneous activity in the developing retina, lateral geniculate nucleus, and visual cortex instruct the axonal and dendritic refinements that give rise to orderly connections in the visual system. Axon guidance cues and a growing list of other molecules, including immune system factors, have also recently been implicated in visual circuit wiring. A major goal now is to determine how these molecules cooperate with spontaneous and visually evoked activity to give rise to the circuits underlying precise receptive field tuning and orderly visual maps. | | Language | eng | | Pub Type(s) | Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
| | PubMed ID | 18558864 |
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